M371 is a qPCR based molecular test to detect germ cell tumors in blood samples. Many of the routine diagnostic steps of a germ cell tumor patient can be minimized, shortened, or even replaced by the liquid biopsy test M371.
M371 is based on the detection of a tumor marker through the established method of qPCR.
Medical Staff is supported in their decision making in primary diagnosis as well as in the monitoring of germ cell tumors by M371.
Unnecessary invasive surgeries may be reduced.
The patient enjoys the highest safety and reliability for their health.
At this moment, M371 is certified for primary diagnosis and monitoring after an orchiectomy.
Further applications will be added in the future.
Biomarkers can be nucleic acids which are released by a tumor into circulation. They are detected as free circulating tumor cells, free DNA (cfDNA) or exosomes (small vehicles that transport e.g., miRNA). Those have the potential to function as biomarkers for specific tumors. Blood, blood serum, blood plasma, urine or other body fluids can be used as a sample.
Liquid biopsy is different to classical biopsy. For a classical biopsy investigation tissue samples were taken from the patient and analyzed microscopically. Contrary to this method, liquid biopsy is faster, only minimally invasive for the patient as it only relies on a body fluid sample (e.g. blood sample) and therefore handled as a potential key-technology in the modern oncology.
qPCR is a molecular diagnostic method to detect and quantify nucleic acids (DNA or RNA). Nucleic acids are usually present in only small quantities in each patient sample. To be reliably detected they must be amplified before they can be quantified.
The unique feature of qPCR is a fluorescent molecule which attaches to each new nucleic acid product that is produced during polymerase chain reaction. When an LED then excites the fluorescent molecule, it emits a signal which can be detected by the qPCR Cycler. The more nucleic acids are produced the stronger the signal gets.
This way already the smallest quantities of nucleic acid can be detected in a patient sample.
To take the sensitivity of the method even further M371 has an additional, patent-protected preamplification step before qPCR which preamplifies the specific biomarker. This modification guarantees the highest sensitivity without increasing the variability of test results.
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mir | detect GmbH
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Dr. Nina Winter
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Register Number: HRB 30218 HB
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personal data any information relating to an identified or identifiable natural person (hereinafter “data subject”); an identifiable natural person is one who can be identified, directly or indirectly, in particular by reference to an identifier such as a name, an identification number, location data, an online identifier or to one or more factors specific to the physical, physiological, genetic, mental, economic, cultural or social identity of that natural person.
data subject means any identified or identifiable natural person whose personal data are processed by the controller of the data.
processing means any operation or set of operations which is performed on personal data or on sets of personal data, whether by automated means, such as collection, recording, organization, structuring, storage, adaptation or alteration, retrieval, consultation, use, disclosure by transmission, dissemination or otherwise making available, alignment or combination, restriction, erasure or destruction.
restriction of processing means the marking of stored personal data with the aim of limiting their processing in the future.
profiling means any form of automated processing of personal data consisting of the use of personal data to evaluate certain personal aspects relating to a natural person, in particular to analyze or predict aspects concerning that natural person’s performance at work, economic situation, health, personal preferences, interests, reliability, behavior, location or movements.
controller means the natural or legal person, public authority, agency or other body which, alone or jointly with others, determines the purposes and means of the processing of personal data; where the purposes and means of such processing are determined by Union or Member State law, the controller or the specific criteria for its nomination may be provided for by Union or Member State law.
recipient means a natural or legal person, public authority, agency, or another body, to which the personal data are disclosed, whether a third party or not. However, public authorities which may receive personal data in the framework of a particular inquiry in accordance with Union or Member State law shall not be regarded as recipients; the processing of those data by those public authorities shall follow the applicable data protection rules according to the purposes of the processing.
third party means a natural or legal person, public authority, agency, or body other than the data subject, controller, processor, and persons who, under the direct authority of the controller or processor, are authorized to process personal data.
consent of the data subject means any freely given, specific, informed, and unambiguous indication of the data subject’s wishes by which he or she, by a statement or by a clear affirmative action, signifies agreement to the processing of personal data relating to him or her.
processor means a natural or legal person, public authority, agency, or other body which processes personal data on behalf of the controller.
The controller within the meaning of the General Data Protection Regulation (GDPR) and other national data protection laws of the Member States as well as other provisions of data protection law is:
Telefon: +49 (0) 421 - 408937110
All visitors and users of our website (hereinafter collectively referred to as "users") are affected within the meaning of the GDPR.
We process the data of the user in individual cases for the following purposes (the following list is not exhaustive; further down in this data protection declaration, further purposes are mentioned under II. if applicable)
As a matter of principle, we collect and use personal data of visitors to our website only to the extent that this is necessary for the provision of a functional website and our content and services. We will neither collect nor use personal data of our users without prior consent of the user. A use or collection of data of our users without a prior explicit consent will only take place exceptionally in cases where a prior obtaining of consent is not possible either for actual reasons or a legal provision allows the processing of the data in exceptional cases.
Art. 6 (1) lit a EU General Data Protection Regulation (GDPR) forms the legal basis in cases where we obtain the express consent of the respective data subject before processing personal data.
In the case of processing of personal data that is necessary for the performance of a contract to which the data subject is a party, Art. 6 (1) lit. c GDPR serves as the legal basis. This also applies to processing operations that are necessary for the implementation of pre-contractual measures.
As far as processing of personal data is necessary for the fulfillment of a legal obligation to which our company is subject, Art. 6 (1) lit c GDPR serves as the legal basis.
If vital interests of the data subject or another natural person make it necessary to process personal data, Art. 6 (1) lit d GDPR serves as the legal basis.
If the processing is necessary to protect a legitimate interest of our company or a third party and the interests, fundamental rights and freedoms of the data subject do not override the first-mentioned interest, Art. 6 (1) lit f GDPR serves as the legal basis for the processing (e.g., When using web hosts, etc.).
The personal data of the data subject shall be deleted or blocked as soon as the purpose of the storage ceases to apply. Storage may take place in accordance with Art. 6 (1) p. 1 lit c GDPR if the purpose of storage has ceased to apply, if this has been provided for by the European or national legislator in Union regulations, laws, or other provisions to which the controller is subject. Blocking or deletion of data will also take place if a storage period prescribed by the aforementioned standards expires (for example, the legislator provides for the retention of personal data in tax law, but also in commercial law; this is regulated in the HGB and the AO; received commercial or business letters must be retained for 6 years).
Each time you visit our website, our system automatically collects data and information from the computer system of the calling computer. This usually is done by the browser used on the user's device automatically forwarding information to the server of our website, whereby this information is temporarily stored in the so-called log file. This regards the following information, which is collected without your active participation solely through the transmission of the browser used by you and is stored on the server of our website until automatic deletion afterwards:
We are processing this information for the following purposes:
Legal basis for data processing is Art. 6 (1) lit. f GDPR.
The temporary storage of the IP address by the system is necessary to enable delivery of the website to the user's computer. For this purpose, the IP address of the user must be stored for the duration of the session.
The data is deleted as soon as it is no longer required to achieve the purpose for which it was collected. In the case of the collection of data for the provision of the website, this is the case when the respective session has ended.
The collection of data for the provision of the website and the storage of the data in log files is necessary for the operation of the website. Consequently, there is no possibility of objection on the part of the user.
You are welcome to contact us via the email address provided by us. If you contact us by email, we will store the personal data of the user transmitted to us with the email. We are not passing on the data to third parties in this context. We use the data exclusively for the processing of the conversation by us.
Legal basis for data processing for the purpose of establishing contact is Art. 6 (1) P. 1 lit. a GDPR in connection with the consent of the user.
If the user reached out by e-mail, this constitutes the necessary legitimate interest in the processing of the data.
We delete the data as soon as they are no longer required to achieve the purpose for which they were collected. Regarding data sent by e-mail, this means that deletion takes place when the respective conversation with the user concerned has ended. We consider the conversation with the user to have ended in this sense as soon as the circumstances indicate that the matter in question has been conclusively clarified.
The user has the possibility to revoke his consent to the processing of personal data at any time. If the user contacts us by email, he can object to the storage of his personal data at any time. In such a case, it is not possible to continue the conversation. All personal data stored while contacting us will be deleted in this case.
A polite approach as well as trouble-free contact with our customers is especially important to us. Therefore, we offer the user a contact form in addition to the usual contact options, which you as a user please refer to our imprint.
It is possible to contact us via the contact form on the website in which personal and other data of the user is requested. As a user, please refer directly to the contact form to find out exactly what data this is. There, at the appropriate place, you can see exactly which data is requested.
If the user enters their personal data (such as name, address, contact information) and other data at the appropriate place in the form, these will be stored by us to be able to process the user's request. Here, too, you as a user naturally have the right to demand information about exactly what data we have stored about you and the right to have this data deleted immediately upon the user's request. The input fields marked with "*" in the respective form are mandatory fields that the user must fill out in order to make the contact request.
Legal basis for data processing for the purpose of establishing contact via contact form is Art. 6 (1) P. 1 lit. a GDPR in connection with the consent of the user.
If the user contacted us by contact form, this constitutes the necessary legitimate interest in the processing of the data.
We delete the data as soon as they are no longer required to achieve the purpose for which they were collected. Regarding data sent by contact form, this means that deletion takes place when the respective conversation with the user concerned has ended. We consider the conversation with the user to have ended in this sense as soon as the circumstances indicate that the matter in question has been conclusively clarified.
The user has the possibility to revoke their consent to the processing of personal data at any time. If the user contacts us by contact form, they can object to the storage of his personal data at any time. In such a case, it is not possible to continue the conversation. All personal data stored while contacting us will be deleted in this case.
In certain situations, we use so-called cookies. A “cookie” is a small text file that is stored in the Internet browser or by the Internet browser on the user's computer system. A cookie can only contain information that we ourselves send to your computer - private data cannot be accessed with it. If you have accepted the cookies on our website, we do not have access to your personal information. With the help of cookies, we are able to identify your computer and to recognize your computer when you visit our website again, thanks to a characteristic string of characters that makes it possible to uniquely identify the browser when you visit the website again. Cookies make our offer more user-friendly, more effective, and safer, as well as help to analyze usage patterns and structures of our website and thus give us clues for optimization according to user behavior. These cookies are deleted as soon as you end the session or close your browser.
The legal basis for processing personal data using cookies is Art. 6 (1) lit f GDPR.
The legal basis for processing personal data using technical essential cookies is Art. 6 (1) lit f GDPR.
The legal basis for the processing of personal data using cookies for analysis purposes is Art. 6 (1) lit. a GDPR if the user has consented to this.
The purpose of using technical essential cookies is to simplify using the website for the user. Some functions of our website can not be offered without using cookies. For these it is necessary that the browser is recognized after changing pages.
Internet Explorer™: http://windows.microsoft.com/de-DE/windows-vista/Block-or-allow-cookies
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We use MapBox API on our website. This is a service of MapBox Inc, 740 15th Street NW, 5th Floor, Washingtons, District of Columbia 20005, USA (hereinafter referred to as MapBox). We use the service of MapBox to visualize geographical information. When using MapBox, MapBox also collects, processes, and uses data about the use of the map function by users of our website. By using the MapBox API, information about the use of this website, including the user's IP address, may be transmitted to MapBox in the USA. MapBox provides in its "Terms of Services" which can be found at the following link: https://www.mapbox.com/tos/#maps
Further information about the use of MapBox and about the data obtained by MapBox from the user. We cannot provide any binding information as to whether and, if so, to which third parties MapBox discloses personal data of the user that MapBox obtains in connection with the use of the MapBox API service. If such processing or disclosure of your data is not desired, you as a user have the option to prevent this (for more details, see 5.4. below).
The legal basis for the processing of personal data using MapBox is Art. 6 (1) lit. f GDPR. Our legitimate interest is to improve the functionality of our website.
The above-described transmission of data to MapBox or the general usage of MapBox is for the economical operation of our website. Furthermore, we use MapBox to visually show you, the user, our location.
We would like to point out that we do not have any knowledge of which data are specifically transmitted to MapBox and how MapBox uses them or how long MapBox stores them. If you as a user of our website do not agree to this processing of your personal data by MapBox, you have the option of preventing the installation of cookies by making the appropriate settings in your Internet browser. For details on this check in this data protection declaration under the point “Cookies”. If you as a user act accordingly and prevent cookies, the use of the MapBox service via our website is no longer possible. MapBox offers further information on the collection and use of data as well as on the rights of users and ways to protect the privacy of users under the following link: https://www.mapbox.com/privacy/
If we pass on personal data of the user in connection with hosting services concerning our website to a third-party provider, we point out that the transfer for the purpose of hosting is necessary to present our website. We were thereby within the context of balancing interests, mainly our justified interests in an accurate presentation of our online offer. We would like to point out that all data provided to us in connection with the use of our website, in particular in connection with filling in online forms provided for this purpose (for example, contact form, online meter reading notification, etc.) are processed on the servers of the third-party provider for the purpose of hosting. We would also like to point out that the corresponding service provider, which has taken over the hosting of our website, is based within a member state of the European Union or the European Economic Area.
The following list includes all rights of data subjects under the GDPR. Rights that have no relevance for your own website do not need to be mentioned. In this respect, the listing can be shortened. If your personal data is processed, you are a data subject within the meaning of the GDPR and you are entitled to the following rights vis-à-vis the controller:
You may request confirmation from the controller as to whether personal data concerning you is being processed by us. If such processing is taking place, you may request the following information from the controller:
You have the right to request information about whether the personal data concerning you is shared with a third country or an international organization. In this context, you may request to be informed about the appropriate guaranties pursuant to Art. 46 GDPR in connection with the transfer.
You have a right to rectification and/or completion vis-à-vis the controller if the personal data processed concerning you is inaccurate or incomplete. The controller shall conduct the rectification without delay.
You can demand from the controller that your personal data shall be erased without delay. The controller is obliged to erase this data without delay if one of the following reasons applies:
If the controller has made the personal data concerning you public and is obliged to erase it pursuant to Article 17(1) of the GDPR, it shall take reasonable steps, including technical measures, having regard to the available technology and the cost of implementation, to inform data controllers processing the personal data that you, as the data subject, have requested that they erase all links to, or copies or replications of, those personal data.
The right to erasure does not exist to the extent that processing is necessary
You may request the restriction of the processing of personal data concerning you under the following conditions:
Where the processing of personal data concerning you has been restricted, the data may be processed, except for storage, only with your consent or for the establishment, exercise, or defense of legal claims or for the protection of the rights of another natural or legal person or for reasons of important public interest of the Union or a Member State.
If the processing has been restricted in accordance with the above conditions, you will be informed by the controller before the restriction is lifted.
If you have asserted the right to rectification, erasure or restriction of processing against the controller, the controller is obliged to notify all recipients to whom the personal data concerning you have been disclosed of this rectification or erasure of the data or restriction of processing, unless this proves impossible or involves a disproportionate effort. It is your right that the controller informs you about these recipients.
You have the right to receive the personal data concerning you that you have provided to the controller in a structured, common, and machine-readable format. In addition, you have the right to transfer this data to another controller without hindrance by the controller to whom the personal data was provided, provided that
In exercising this right, you also have the right to obtain that the personal data concerning you be transferred directly from one controller to another controller, as far as this is technically feasible. This must not affect freedoms and rights of other persons. The right to data portability does not apply to processing of personal data necessary for the performance of a task conducted in the public interest or in the exercise of official authority vested in the controller.
You have the right to object at any time, on grounds relating to your particular situation, to the processing of personal data relating to you which is carried out on the basis of Art. 6(1)(e) or (f) GDPR; this also applies to profiling based on these provisions. The controller will no longer process the personal data concerning you unless it can demonstrate compelling legitimate grounds for the processing which override your interests, rights and freedoms, or the processing serves the purpose of asserting, exercising, or defending legal claims. If the personal data concerning you are processed for the purposes of direct marketing, you have the right to object at any time to processing of the personal data concerning you for the purposes of such marketing; this also applies to profiling, insofar as it is related to such direct marketing, the personal data concerning you will no longer be processed for these purposes. You have the possibility, in connection with the use of information society services - notwithstanding Directive 2002/58/EC - to exercise your right to object by means of automated procedures using technical specifications. To exercise your right to object, it is sufficient if you send us an e-mail to the following e-mail address: email@example.com
You have the right to revoke your declaration of consent under data protection law at any time. The revocation of consent does not affect the lawfulness of the processing carried out based on the consent until the revocation. To exercise your right to object, it is sufficient to send us an e-mail to the following e-mail address: firstname.lastname@example.org
ou have the right not to be subject to a decision based solely on automated processing - including profiling - which produces legal effects concerning you or similarly significantly affects you. This does not apply if the decision
However, these decisions may not be based on special categories of personal data pursuant to Art. 9(1) GDPR, unless Art. 9(2)(a) or (g) GDPR applies, and appropriate measures have been taken to protect the rights and freedoms as well as your legitimate interests. With regard to the cases referred to in (1) and (3), the controller shall take reasonable steps to safeguard the rights and freedoms of, and the legitimate interests of, the data subject, which shall include, at least, the right to obtain the intervention of a person on the part of the controller, to express his or her point of view and to contest the decision.
Without prejudice to any other administrative or judicial remedy, you have the right to lodge a complaint with a supervisory authority, in particular in the Member State of your residence, place of work or the place of the alleged infringement, if you consider that the processing of personal data concerning you infringes the GDPR. The supervisory authority to which the complaint has been lodged shall inform the complainant of the status and outcome of the complaint, including the possibility of a judicial remedy under Article 78 GDPR.
We use appropriate technical and organizational security measures to protect your data against intentional or accidental manipulation by third parties, partial or complete loss, destruction or against unauthorized access by third parties. We attach great importance to constantly adapting and further developing the security measures we use to the state of the art.