we discover ...
mir|detect has developed an innovative patented method to improve the sensitivity of liquid biopsy tests while ensuring the safety of the test results. The technology of mir|detect is based on the quantification of specific nucleic acids released by tumor cells and detectable in the patient sample. By targeted identification of these biomarkers, the accuracy and reliability of the test results could be significantly increased.
The method developed by mir|detect represents a significant step towards improving the quality of life for their patients.
Our liquid biopsy procedure has the potential to improve the diagnosis and treatment process for patients, medical personnel, and insurers at every level. It enables faster and more individualized therapy decisions, and ultimately the possibility of cost savings. By detecting small amounts of tumor-specific nucleic acids in a blood sample, liquid biopsy tests can also be used in primary diagnosis to make a clear diagnosis more quickly and safely.
The method developed by mir|detect is of great importance not only in primary diagnosis but also particularly in follow-up care.
By detecting cancer-specific molecules in blood samples at an early stage, doctors can react more quickly and effectively to the course of the disease. In follow-up care, liquid biopsy tests can help detect recurring tumors early and offer patients personalized treatment.
In follow-up care, liquid biopsy tests from mir|detect can also play a crucial role. Early and reliable detection of recurrences can ensure personalized treatment for the patient without the excessive use of toxic radiation for imaging techniques. By identifying specific biomarkers, the sensitivity of the tests can be increased once again, thereby increasing safety for the patient.
Biomarkers can be nucleic acids which are released by a tumor into circulation. They are detected as free circulating tumor cells, free DNA (cfDNA) or exosomes (small vehicles that transport e.g., miRNA). Those have the potential to function as biomarkers for specific tumors. Blood, blood serum, blood plasma, urine or other body fluids can be used as a sample.
Liquid biopsy is different to classical biopsy. For a classical biopsy investigation tissue samples were taken from the patient and analyzed microscopically. Contrary to this method, liquid biopsy is faster, only minimally invasive for the patient as it only relies on a body fluid sample (e.g. blood sample) and therefore handled as a potential key-technology in the modern oncology.
qPCR is a molecular diagnostic method to detect and quantify nucleic acids (DNA or RNA). Nucleic acids are usually present in only small quantities in each patient sample. To be reliably detected they must be amplified before they can be quantified.
The unique feature of qPCR is a fluorescent molecule which attaches to each new nucleic acid product that is produced during polymerase chain reaction. When an LED then excites the fluorescent molecule, it emits a signal which can be detected by the qPCR Cycler. The more nucleic acids are produced the stronger the signal gets.
This way already the smallest quantities of nucleic acid can be detected in a patient sample.
To take the sensitivity of the method even further M371 has an additional, patent-protected preamplification step before qPCR which preamplifies the specific biomarker. This modification guarantees the highest sensitivity without increasing the variability of test results.
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mir | detect GmbH
Chief Executive Officer
Dr. Nina Winter
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ou have the right not to be subject to a decision based solely on automated processing - including profiling - which produces legal effects concerning you or similarly significantly affects you. This does not apply if the decision
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